pediatric hematology
Contributions
Type: Publication Only
Background
Hepatitis C virus (HCV) is a major cause of chronic hepatitis C (CHC) which increases the risk for insulin resistance, glucose intolerance and type 2 diabetes. Egypt has the highest reported rates of HCV infection especially among chronically transfused patients. Abnormal glucose tolerance is common in multitransfused thalassemia and is attributed to early impaired beta cells function with increasing insulin resistance (IR). The HOMA index (homeostasis model assessment) has been extensively used to investigate insulin resistance in CHC
Aims
to detect insulin resistance in transfusion dependent thalassemia major patients and to evaluate its possible link to chronic hepatitis and iron overload
Methods
: Fifty nine Egyptian thalassemia major patients were divided into hepatitis C (HCV) positive (group A; n= 39) and HCV negative thalassemics (group B; n=20) by HCV antibody and RNA. Thalassemia patients were compared to 20 age and sex matched HCV positive (non thalassemic) patients (group C). Blood samples were withdrawn from all patients for assessment of HOMA index, serum ferritin, AST and ALT
Results
: Abnormal HOMA test was evident in 30.8% (n=12) of group A and 40% (n=8) of the control group while none of group B had abnormal test. Significant results of HOMA-IR was observed between the three groups (p=0.029) and between group B and each of groups A and C (p= 0.012, 0.043 respectively) while no difference was observed between HCV positive thalassemics and control group (p=0.99) Positive correlation (p=0.038) was observed between HOMA- IR and AST but no correlation to age or serum ferritin level
Summary
Chronic Hepatitis in transfusion dependent thalassemia major patients is a major risk factor for insulin resistance in these patients
Keyword(s): Thalassemia
Session topic: Publication Only
Type: Publication Only
Background
Hepatitis C virus (HCV) is a major cause of chronic hepatitis C (CHC) which increases the risk for insulin resistance, glucose intolerance and type 2 diabetes. Egypt has the highest reported rates of HCV infection especially among chronically transfused patients. Abnormal glucose tolerance is common in multitransfused thalassemia and is attributed to early impaired beta cells function with increasing insulin resistance (IR). The HOMA index (homeostasis model assessment) has been extensively used to investigate insulin resistance in CHC
Aims
to detect insulin resistance in transfusion dependent thalassemia major patients and to evaluate its possible link to chronic hepatitis and iron overload
Methods
: Fifty nine Egyptian thalassemia major patients were divided into hepatitis C (HCV) positive (group A; n= 39) and HCV negative thalassemics (group B; n=20) by HCV antibody and RNA. Thalassemia patients were compared to 20 age and sex matched HCV positive (non thalassemic) patients (group C). Blood samples were withdrawn from all patients for assessment of HOMA index, serum ferritin, AST and ALT
Results
: Abnormal HOMA test was evident in 30.8% (n=12) of group A and 40% (n=8) of the control group while none of group B had abnormal test. Significant results of HOMA-IR was observed between the three groups (p=0.029) and between group B and each of groups A and C (p= 0.012, 0.043 respectively) while no difference was observed between HCV positive thalassemics and control group (p=0.99) Positive correlation (p=0.038) was observed between HOMA- IR and AST but no correlation to age or serum ferritin level
Summary
Chronic Hepatitis in transfusion dependent thalassemia major patients is a major risk factor for insulin resistance in these patients
Keyword(s): Thalassemia
Session topic: Publication Only