HYPERFERRITINEMIA IS ASSOCIATED WITH IMPAIRED SURVIVAL IN PATIENTS DIAGNOSED WITH MYELODYSPLASTIC SYNDROMES ? RESULTS FROM THE FIRST POLISH MDS REGISTRY
(Abstract release date: 05/21/15)
EHA Library. Waszczuk-Gajda A. 06/12/15; 102869; PB1826
Disclosure(s): Public Central Teaching Hospital Address: 1a, Banacha Str., 02-097 WarsawDepartment of Hematology, Oncology and Internal Diseases
Anna Waszczuk-Gajda
Contributions
Contributions
Abstract
Abstract: PB1826
Type: Publication Only
Background
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia (AML).
Aims
The influence of serum ferritin concentration on survival and acute myeloid leukemia transformation in MDS patients remains controversial. The data for Central European population is scarce and so far there is no description for Poland. Aim of this study was to perform an retrospective analysis of relationship of ferritin concentration with red blood cell transfusion dependency, survival and acute myelogeneous leukemia transformation.
Methods
We retrospectively evaluated data of the 819 MDS patients (58% male; median age 70 years), included in the MDS Registry of the Polish Adult Leukemia Group (PALG). Analysis was performed for 190 patients diagnosed with MDS maximal 6 months before inclusion to registry in order to avoid selection bias (shorter survival of higher risk MDS patients).
Results
Patients with hyperferritinemia higher than 1000 ng/l versus patients with ferritin concentration lower than 1000 ng/l had median survival of 320 days vs 568 days respectively (p log-rank=0.014). It was shown that the following factors significantly worsened survival: ferritin concentration higher than 1000 ng/l (p=0.0023; HR=2.94), RBC-transfusions dependence (p=0.0033; HR 2.671), platelet transfusions dependence (p=0.0033; HR 2.671), hemoglobin concentration lower than 10 g/dl (p=0.0036; HR 2.97), platelet count lower than 10 G/l (p=0.0081 HR=5.04), acute leukemia transformation (p=0.0081; HR 1.968).
Summary
Taking into account relatively low number of patients in previous studies exploring the topic of hyperferritinemia in MDS patients, the study provides important insights.
Keyword(s): Ferritin, Myelodysplasia, Transformation, Transfusion
Session topic: Publication Only
Type: Publication Only
Background
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia (AML).
Aims
The influence of serum ferritin concentration on survival and acute myeloid leukemia transformation in MDS patients remains controversial. The data for Central European population is scarce and so far there is no description for Poland. Aim of this study was to perform an retrospective analysis of relationship of ferritin concentration with red blood cell transfusion dependency, survival and acute myelogeneous leukemia transformation.
Methods
We retrospectively evaluated data of the 819 MDS patients (58% male; median age 70 years), included in the MDS Registry of the Polish Adult Leukemia Group (PALG). Analysis was performed for 190 patients diagnosed with MDS maximal 6 months before inclusion to registry in order to avoid selection bias (shorter survival of higher risk MDS patients).
Results
Patients with hyperferritinemia higher than 1000 ng/l versus patients with ferritin concentration lower than 1000 ng/l had median survival of 320 days vs 568 days respectively (p log-rank=0.014). It was shown that the following factors significantly worsened survival: ferritin concentration higher than 1000 ng/l (p=0.0023; HR=2.94), RBC-transfusions dependence (p=0.0033; HR 2.671), platelet transfusions dependence (p=0.0033; HR 2.671), hemoglobin concentration lower than 10 g/dl (p=0.0036; HR 2.97), platelet count lower than 10 G/l (p=0.0081 HR=5.04), acute leukemia transformation (p=0.0081; HR 1.968).
Summary
Taking into account relatively low number of patients in previous studies exploring the topic of hyperferritinemia in MDS patients, the study provides important insights.
Keyword(s): Ferritin, Myelodysplasia, Transformation, Transfusion
Session topic: Publication Only
Abstract: PB1826
Type: Publication Only
Background
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia (AML).
Aims
The influence of serum ferritin concentration on survival and acute myeloid leukemia transformation in MDS patients remains controversial. The data for Central European population is scarce and so far there is no description for Poland. Aim of this study was to perform an retrospective analysis of relationship of ferritin concentration with red blood cell transfusion dependency, survival and acute myelogeneous leukemia transformation.
Methods
We retrospectively evaluated data of the 819 MDS patients (58% male; median age 70 years), included in the MDS Registry of the Polish Adult Leukemia Group (PALG). Analysis was performed for 190 patients diagnosed with MDS maximal 6 months before inclusion to registry in order to avoid selection bias (shorter survival of higher risk MDS patients).
Results
Patients with hyperferritinemia higher than 1000 ng/l versus patients with ferritin concentration lower than 1000 ng/l had median survival of 320 days vs 568 days respectively (p log-rank=0.014). It was shown that the following factors significantly worsened survival: ferritin concentration higher than 1000 ng/l (p=0.0023; HR=2.94), RBC-transfusions dependence (p=0.0033; HR 2.671), platelet transfusions dependence (p=0.0033; HR 2.671), hemoglobin concentration lower than 10 g/dl (p=0.0036; HR 2.97), platelet count lower than 10 G/l (p=0.0081 HR=5.04), acute leukemia transformation (p=0.0081; HR 1.968).
Summary
Taking into account relatively low number of patients in previous studies exploring the topic of hyperferritinemia in MDS patients, the study provides important insights.
Keyword(s): Ferritin, Myelodysplasia, Transformation, Transfusion
Session topic: Publication Only
Type: Publication Only
Background
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia (AML).
Aims
The influence of serum ferritin concentration on survival and acute myeloid leukemia transformation in MDS patients remains controversial. The data for Central European population is scarce and so far there is no description for Poland. Aim of this study was to perform an retrospective analysis of relationship of ferritin concentration with red blood cell transfusion dependency, survival and acute myelogeneous leukemia transformation.
Methods
We retrospectively evaluated data of the 819 MDS patients (58% male; median age 70 years), included in the MDS Registry of the Polish Adult Leukemia Group (PALG). Analysis was performed for 190 patients diagnosed with MDS maximal 6 months before inclusion to registry in order to avoid selection bias (shorter survival of higher risk MDS patients).
Results
Patients with hyperferritinemia higher than 1000 ng/l versus patients with ferritin concentration lower than 1000 ng/l had median survival of 320 days vs 568 days respectively (p log-rank=0.014). It was shown that the following factors significantly worsened survival: ferritin concentration higher than 1000 ng/l (p=0.0023; HR=2.94), RBC-transfusions dependence (p=0.0033; HR 2.671), platelet transfusions dependence (p=0.0033; HR 2.671), hemoglobin concentration lower than 10 g/dl (p=0.0036; HR 2.97), platelet count lower than 10 G/l (p=0.0081 HR=5.04), acute leukemia transformation (p=0.0081; HR 1.968).
Summary
Taking into account relatively low number of patients in previous studies exploring the topic of hyperferritinemia in MDS patients, the study provides important insights.
Keyword(s): Ferritin, Myelodysplasia, Transformation, Transfusion
Session topic: Publication Only
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