pharmacy oran
Contributions
Type: Publication Only
Background
Factor II deficiency is one of the rare inherited bleeding disorders the frequency in world is 1/ 2*106. But in algeria there is high consanguinity rates have increased the number of patients with Rare Bleeding Disorders (RBDs)
Aims
-It was established a clinical and biological classification of patients with rare deficiency disorders.
- It was explored the relationship between coagulation factor activity level and bleeding severity for this patients.
Methods
A retrospective study conduct from 2008 to 2014.
It was concerned 63 patients with a mean age 29 years (range1 year to 73 years) and Sex ratio ?/? = 1.17.
We use assigned categories of clinical bleeding severity of The European Network of Rare Bleeding Disorders (EN-RBD) :
1 . Asymptomatic : No documented bleeding episodes
2. Grade I : bleeding Bleeding that occurred after trauma or drug ingestion (antiplatelet or anticoagulant therapy)
3. Grade II :bleeding Spontaneous minor bleeding:bruising, ecchymosis, minor
wounds, oral cavity bleeding, epistaxis and menorrhagia.
4.Grade III : bleeding Spontaneous major bleeding: hematomas*, hemarthrosis, central nervous system,gastrointestinal and umbilical cord bleeding.
Results
06 patients (09.5%) of RBDs were diagnosed with Factor II deficiency,
Clinical bleeding showed that the most common symptoms in patients with FII deficiency were oral cavity bleeding(34%), followed by hematomas(17%) , epistaxis (17%) .
Summary
Any association between bleeding manifestations and residual FII coagulant activity in plasma was found, but is very difficult to ascertain this association because the small number of reported cases. However, 03 patients with FII coagulant activity < 10% reported to be associated with severe bleeding manifestations grade II and III.and a weak direct correlation between laboratory severity and the age at first bleed was noted.
Type: Publication Only
Background
Factor II deficiency is one of the rare inherited bleeding disorders the frequency in world is 1/ 2*106. But in algeria there is high consanguinity rates have increased the number of patients with Rare Bleeding Disorders (RBDs)
Aims
-It was established a clinical and biological classification of patients with rare deficiency disorders.
- It was explored the relationship between coagulation factor activity level and bleeding severity for this patients.
Methods
A retrospective study conduct from 2008 to 2014.
It was concerned 63 patients with a mean age 29 years (range1 year to 73 years) and Sex ratio ?/? = 1.17.
We use assigned categories of clinical bleeding severity of The European Network of Rare Bleeding Disorders (EN-RBD) :
1 . Asymptomatic : No documented bleeding episodes
2. Grade I : bleeding Bleeding that occurred after trauma or drug ingestion (antiplatelet or anticoagulant therapy)
3. Grade II :bleeding Spontaneous minor bleeding:bruising, ecchymosis, minor
wounds, oral cavity bleeding, epistaxis and menorrhagia.
4.Grade III : bleeding Spontaneous major bleeding: hematomas*, hemarthrosis, central nervous system,gastrointestinal and umbilical cord bleeding.
Results
06 patients (09.5%) of RBDs were diagnosed with Factor II deficiency,
Clinical bleeding showed that the most common symptoms in patients with FII deficiency were oral cavity bleeding(34%), followed by hematomas(17%) , epistaxis (17%) .
Summary
Any association between bleeding manifestations and residual FII coagulant activity in plasma was found, but is very difficult to ascertain this association because the small number of reported cases. However, 03 patients with FII coagulant activity < 10% reported to be associated with severe bleeding manifestations grade II and III.and a weak direct correlation between laboratory severity and the age at first bleed was noted.