Hematology
Contributions
Type: Publication Only
Background
Cardiovascular diseases,thrombohemorrhagic complications, bone marrow failure due to myelofibrosis and leukemic transformation are the major causes of mortality and morbidity in patients with Philadelphia negative chronic myeloproliferative neoplasms (MPNs). Chronic inflammation is also suggested to play a role in the development of atherosclerosis in this group of patients.
Aims
We aimed to evaluate the prevalance of subclinical atherosclerosis in patients with essential thrombocythemia and polistemia vera with the terms of conventional risk factors like lipid profile and carotid intima media thickness (CIMT).
Methods
100 patients with Philadelphia negative chronic MPN and 50 age and gender matched healthy controls were enrolled in our study. We determined the lipid profile, fasting blood glucose, body mass index and CIMT of both groups.
Results
Mean age of patient group was 58.46 years (26-86 years). 44 were female (44%) and 56 were male (56%). In the control group, mean age was 58.68 years (37-67 years), 24 were female (48%) and 26 were male (52%). Duration of disease was 1 to 14 years (mean 5.81). In the medical history of patients venous thromboembolism was present in 10 patients (10%) and arterial thromboembolism was present in 28 patients (28%). 1 patient had diabetes (1%) and 34 patients had hypertension (34%).
Levels of cholesterol, LDL, HDL, triglyceride, fasting blood glucose and body mass indexes were similar in both groups. Over 1 cm thickness was accepted as plaque. Plaque was observed on the right in 3 patients (%3) while on the left in 8 patients (%8). No patients had plaque on both carotid arteries. In the control group, 3 patient had plaque on the right carotid artery (6%) and 2 patient had on the left carotid artery (4%, total 10%)
CIMT was related with age, disease duration, body mass index, levels of total cholesterol, LDL and absolute leucocyte count while not related with gender, fasting blood glucose, levels of HDL, triglyceride, hemoglobin, hematocrite and thrombocytes. Logistic regression analysis of age, disease duration and presence of plaque showed a relation with disease duration and presence of plaque (p=0.001). In patients with a history of arterial thrombosis, 6 had plaque (21.4%) while in patients with a history of venous thrombosis, 5 was observed to have plaque (50%), though no relation was observed with logistic regression analysis.
Summary
During the course of chronic MPNs, a chonic inflammatory process with thromboembolic complications is certain. Development of subclinical atherosclerosis is related with traditional risk factors like hypercholesterolemia as well as disease duration independent of age.
Keyword(s): Atherosclerosis, Myeloproliferative disorder
Session topic: Publication Only
Type: Publication Only
Background
Cardiovascular diseases,thrombohemorrhagic complications, bone marrow failure due to myelofibrosis and leukemic transformation are the major causes of mortality and morbidity in patients with Philadelphia negative chronic myeloproliferative neoplasms (MPNs). Chronic inflammation is also suggested to play a role in the development of atherosclerosis in this group of patients.
Aims
We aimed to evaluate the prevalance of subclinical atherosclerosis in patients with essential thrombocythemia and polistemia vera with the terms of conventional risk factors like lipid profile and carotid intima media thickness (CIMT).
Methods
100 patients with Philadelphia negative chronic MPN and 50 age and gender matched healthy controls were enrolled in our study. We determined the lipid profile, fasting blood glucose, body mass index and CIMT of both groups.
Results
Mean age of patient group was 58.46 years (26-86 years). 44 were female (44%) and 56 were male (56%). In the control group, mean age was 58.68 years (37-67 years), 24 were female (48%) and 26 were male (52%). Duration of disease was 1 to 14 years (mean 5.81). In the medical history of patients venous thromboembolism was present in 10 patients (10%) and arterial thromboembolism was present in 28 patients (28%). 1 patient had diabetes (1%) and 34 patients had hypertension (34%).
Levels of cholesterol, LDL, HDL, triglyceride, fasting blood glucose and body mass indexes were similar in both groups. Over 1 cm thickness was accepted as plaque. Plaque was observed on the right in 3 patients (%3) while on the left in 8 patients (%8). No patients had plaque on both carotid arteries. In the control group, 3 patient had plaque on the right carotid artery (6%) and 2 patient had on the left carotid artery (4%, total 10%)
CIMT was related with age, disease duration, body mass index, levels of total cholesterol, LDL and absolute leucocyte count while not related with gender, fasting blood glucose, levels of HDL, triglyceride, hemoglobin, hematocrite and thrombocytes. Logistic regression analysis of age, disease duration and presence of plaque showed a relation with disease duration and presence of plaque (p=0.001). In patients with a history of arterial thrombosis, 6 had plaque (21.4%) while in patients with a history of venous thrombosis, 5 was observed to have plaque (50%), though no relation was observed with logistic regression analysis.
Summary
During the course of chronic MPNs, a chonic inflammatory process with thromboembolic complications is certain. Development of subclinical atherosclerosis is related with traditional risk factors like hypercholesterolemia as well as disease duration independent of age.
Keyword(s): Atherosclerosis, Myeloproliferative disorder
Session topic: Publication Only