The 2012 FDA approval of subcutaneous (SC) bortezomib (BTZ) was based on non-inferior efficacy and reduced toxicity vs intravenous (IV) administration of BTZ. While differences in BTZ toxicity are attributed to route, dose, schedule, and duration, little is known about BTZ use in recent real-world practice in the US.
Patients (pts) with relapsed/refractory (R/R) multiple myeloma (MM) were selected from a longitudinal, nationally-representative electronic medical record (EMR) database (Flatiron Health). MM diagnoses were confirmed by physician (MD) notes. Pts were required to have disease progression following 1st line of therapy (LOT), ≥ 1 visit after 2010, and ≥ 3 months follow-up post-progression. Pt-level data were integrated from structured and unstructured EMR sources: transplant status abstracted from MD notes and IV/SC administration data merged with oral data from MD notes. We evaluated BTZ usage among these pts with R/R MM.
The 2012 FDA approval of subcutaneous (SC) bortezomib (BTZ) was based on non-inferior efficacy and reduced toxicity vs intravenous (IV) administration of BTZ. While differences in BTZ toxicity are attributed to route, dose, schedule, and duration, little is known about BTZ use in recent real-world practice in the US.
Patients (pts) with relapsed/refractory (R/R) multiple myeloma (MM) were selected from a longitudinal, nationally-representative electronic medical record (EMR) database (Flatiron Health). MM diagnoses were confirmed by physician (MD) notes. Pts were required to have disease progression following 1st line of therapy (LOT), ≥ 1 visit after 2010, and ≥ 3 months follow-up post-progression. Pt-level data were integrated from structured and unstructured EMR sources: transplant status abstracted from MD notes and IV/SC administration data merged with oral data from MD notes. We evaluated BTZ usage among these pts with R/R MM.