Pediatric Hematology
Contributions
Type: Publication Only
Background
Lipid peroxidation increased in iron defiency anemia (IDA) as a result of increase capasity of oxydant and also decreases of antioxydant capasity. Though there are many studies that damaged antioxydant activity affects atherogenonosus in IDA; there are not any studies over intima-media thickness of carotid artery (CIMT).
Aims
The aim of this study is to assess the antioxydant enzym activity in iron defiency (ID) without anemiea and thickness of carotid intima media as an early indicator of premature of atherosclerosis.
Methods
In this study, we searched for the relationship between carotid intima-media thickness and antioxidant enzyme activities in adolescents with iron deficiency or IDA. The study was performed on 71 children aged 11 to 17 years old including 25 children with ID, 25 children with IDA and 21 healthy children. Complete blood count, the serum levels of iron and iron binding capacity, ferritin, lipid profile, glutathione peroxidase, glutathione reductase, paraoxonase activity were carried out. The CIMT were assessed by using echocardiography. All blood tests and CIMT were reevaluated after three months oral ferric iron treatment in the group with iron deficiency anemia.
Results
We founded significantly lower paraoxonase activity in groups of iron deficiency and iron deficiency anemia (p<0.05), but there was not a difference between this two groups. In addition, glutathione peroxidase and reductase activities were similar (p>0.05). CIMT in ID and IDA were higher than the control group (p<0.05), but there was not a difference between this two groups. After the iron treatment, significantly increased PON, GSH-Px, GSH-R activities (p<0.05) and CIMT were decreased. It has been determined that a significant correlation between PON enzyme activity and levels of hemoglobin, serum iron, ferritin, serum transferrin saturation. Moreover, there was an inverse correlation between carotid intima thickness and levels of hemoglobin, ferritin, and serum transferrin saturation. It was also revealed PON was negatively correlated with CIMT in IDA group (p<0.05, r: -0.410).
Summary
We think that impaired antioxydant capasity exist during iron defiency without anemia and this lead up to atherosclerosis. In addition, iron defiency even if not anemia should be treated to prevent prematüre aterosclerosis
Keyword(s): Antioxidants, Children, Iron deficiency anemia
Session topic: Publication Only
Type: Publication Only
Background
Lipid peroxidation increased in iron defiency anemia (IDA) as a result of increase capasity of oxydant and also decreases of antioxydant capasity. Though there are many studies that damaged antioxydant activity affects atherogenonosus in IDA; there are not any studies over intima-media thickness of carotid artery (CIMT).
Aims
The aim of this study is to assess the antioxydant enzym activity in iron defiency (ID) without anemiea and thickness of carotid intima media as an early indicator of premature of atherosclerosis.
Methods
In this study, we searched for the relationship between carotid intima-media thickness and antioxidant enzyme activities in adolescents with iron deficiency or IDA. The study was performed on 71 children aged 11 to 17 years old including 25 children with ID, 25 children with IDA and 21 healthy children. Complete blood count, the serum levels of iron and iron binding capacity, ferritin, lipid profile, glutathione peroxidase, glutathione reductase, paraoxonase activity were carried out. The CIMT were assessed by using echocardiography. All blood tests and CIMT were reevaluated after three months oral ferric iron treatment in the group with iron deficiency anemia.
Results
We founded significantly lower paraoxonase activity in groups of iron deficiency and iron deficiency anemia (p<0.05), but there was not a difference between this two groups. In addition, glutathione peroxidase and reductase activities were similar (p>0.05). CIMT in ID and IDA were higher than the control group (p<0.05), but there was not a difference between this two groups. After the iron treatment, significantly increased PON, GSH-Px, GSH-R activities (p<0.05) and CIMT were decreased. It has been determined that a significant correlation between PON enzyme activity and levels of hemoglobin, serum iron, ferritin, serum transferrin saturation. Moreover, there was an inverse correlation between carotid intima thickness and levels of hemoglobin, ferritin, and serum transferrin saturation. It was also revealed PON was negatively correlated with CIMT in IDA group (p<0.05, r: -0.410).
Summary
We think that impaired antioxydant capasity exist during iron defiency without anemia and this lead up to atherosclerosis. In addition, iron defiency even if not anemia should be treated to prevent prematüre aterosclerosis
Keyword(s): Antioxidants, Children, Iron deficiency anemia
Session topic: Publication Only