TRANSIENT RED CELL APLASIA 'THE GIFT OF PROGRESS'
(Abstract release date: 05/21/15)
EHA Library. Vaynyunskaya N. 06/12/15; 102787; PB2012
Disclosure(s): Saint-Petersburg State Medical Hospital 1
Nadezda Vaynyunskaya
Contributions
Contributions
Abstract
Abstract: PB2012
Type: Publication Only
Background
“What we call progress is the replacement of one trouble to another”,H.Ellis. Modern technologies that enabling blood transfusion even in utero, possibilities to identify new viruses and so on that is a background why doctors have to solve previously never-existing problems.Transient aplasia crisis is an often situation for the pediatric hematologist in Russia. It would seems strange, but we have decided to unite under this name two quite different nosological forms:hemolytic disease of the newborn,complicated with an absence of reticulocytosis, and transient erythroblastopenia of childhood.
Aims
To analyze the clinical features and management of aplasia crisis in children with hemolytic disease of newborns, complicated with an absence of reticulocytosis and children with transient erythroblastopenia.
Methods
There were reviewed medical histories of 62 patients (16 babies with hemolytic disease of the newborn, complicated absence of reticulocytosis, 46 children with transient erythroblastopenia of childhood). We have evaluated duration of hospitalization, number of transfusions,the connection of the disease with infection, therapeutic options. Period of evaluation was since 2009 to 2014 years.
Results
Children with hemolytic disease of the newborn were aged from 0 to 3. Children with transient erythroblastopenia of childhood were aged from 12 months to 5 years.The length of hospitalization of children ranged from 16 days to 35 days, the average was 24 days, and from 9 to 25 days on average 16 days, respectively.Children with hemolytic disease of the newborn were closely observed immediately after birth, and were admitted to hospital in adequate time. Only 12 of the 46 children with transient erythroblastopenia of childhood were applied to hospital immediately after infection. During the observation period the number of patients with transient erythroblastopenia of childhood increased from 7 (2009) to 15 (2014).Children with hemolytic disease of the newborn has increased from 3 (2009) to 5 (2014).6 children with hemolytic disease of the newborn required intrauterine transfusions, 9 children required exchange transfusion immediately after birth, 12 babies needed transfusion during the first month of life.There were 21 child with transient erythroblastopenia of childhood that required blood transfusions because of the hemic hypoxia signs.In 18 children with transient erythroblastopenia of childhood was verified acute viral infection (6 EBV,2 Parvovirus 19,4 CMV, 5 herpes virus type 6,1 herpes type 1).In children with hemolytic disease of the newborn, complicated by aplastic crisis, acute viral infections has not been found. Two children with severe long regenerating form of hemolytic disease of the newborn held a bone marrow biopsy, to 44 patients with erythroblastopenia was also made this study.According to the results of myelogram in all patients there was excluded systemic blood diseases. All patients with hemolytic disease of the newborn received drugs of erythropoietin from 5 to 15 injections depending on the severity of the condition . Reticulocytosis crisis was reached in an average of 4-5 injections. All patients with erythroblastopenia received B group vitamins, 16 children received a course of prednisolone. Children with erythroblastopenia had normalization of blood count at 12-25 day.
Summary
Transient aplasia crisis, that presented by normochromic aregenerating anemia, is severe, but in the modern world, treatable condition. Duration and severity of hemolytic disease of the newborn regenerating status is determined by prenatal transfusion therapy. Severity and length of transient erythroblastopenia of childhood is determined by the etiology of the infectious agent and the time of anemia status. Parvovirus B19 is not the only reason for the erythroblastopenia of childhood.Both of these diseases are relatively benign conditions, it can pass without trace, but in view of the high transfusion dependence it requires further study and observation. Regularly blood tests after birth and diseases can help to find this conditions earlier and to reduce transfusion rate.
Keyword(s): Bone Marrow, Red blood cell
Session topic: Publication Only
Type: Publication Only
Background
“What we call progress is the replacement of one trouble to another”,H.Ellis. Modern technologies that enabling blood transfusion even in utero, possibilities to identify new viruses and so on that is a background why doctors have to solve previously never-existing problems.Transient aplasia crisis is an often situation for the pediatric hematologist in Russia. It would seems strange, but we have decided to unite under this name two quite different nosological forms:hemolytic disease of the newborn,complicated with an absence of reticulocytosis, and transient erythroblastopenia of childhood.
Aims
To analyze the clinical features and management of aplasia crisis in children with hemolytic disease of newborns, complicated with an absence of reticulocytosis and children with transient erythroblastopenia.
Methods
There were reviewed medical histories of 62 patients (16 babies with hemolytic disease of the newborn, complicated absence of reticulocytosis, 46 children with transient erythroblastopenia of childhood). We have evaluated duration of hospitalization, number of transfusions,the connection of the disease with infection, therapeutic options. Period of evaluation was since 2009 to 2014 years.
Results
Children with hemolytic disease of the newborn were aged from 0 to 3. Children with transient erythroblastopenia of childhood were aged from 12 months to 5 years.The length of hospitalization of children ranged from 16 days to 35 days, the average was 24 days, and from 9 to 25 days on average 16 days, respectively.Children with hemolytic disease of the newborn were closely observed immediately after birth, and were admitted to hospital in adequate time. Only 12 of the 46 children with transient erythroblastopenia of childhood were applied to hospital immediately after infection. During the observation period the number of patients with transient erythroblastopenia of childhood increased from 7 (2009) to 15 (2014).Children with hemolytic disease of the newborn has increased from 3 (2009) to 5 (2014).6 children with hemolytic disease of the newborn required intrauterine transfusions, 9 children required exchange transfusion immediately after birth, 12 babies needed transfusion during the first month of life.There were 21 child with transient erythroblastopenia of childhood that required blood transfusions because of the hemic hypoxia signs.In 18 children with transient erythroblastopenia of childhood was verified acute viral infection (6 EBV,2 Parvovirus 19,4 CMV, 5 herpes virus type 6,1 herpes type 1).In children with hemolytic disease of the newborn, complicated by aplastic crisis, acute viral infections has not been found. Two children with severe long regenerating form of hemolytic disease of the newborn held a bone marrow biopsy, to 44 patients with erythroblastopenia was also made this study.According to the results of myelogram in all patients there was excluded systemic blood diseases. All patients with hemolytic disease of the newborn received drugs of erythropoietin from 5 to 15 injections depending on the severity of the condition . Reticulocytosis crisis was reached in an average of 4-5 injections. All patients with erythroblastopenia received B group vitamins, 16 children received a course of prednisolone. Children with erythroblastopenia had normalization of blood count at 12-25 day.
Summary
Transient aplasia crisis, that presented by normochromic aregenerating anemia, is severe, but in the modern world, treatable condition. Duration and severity of hemolytic disease of the newborn regenerating status is determined by prenatal transfusion therapy. Severity and length of transient erythroblastopenia of childhood is determined by the etiology of the infectious agent and the time of anemia status. Parvovirus B19 is not the only reason for the erythroblastopenia of childhood.Both of these diseases are relatively benign conditions, it can pass without trace, but in view of the high transfusion dependence it requires further study and observation. Regularly blood tests after birth and diseases can help to find this conditions earlier and to reduce transfusion rate.
Keyword(s): Bone Marrow, Red blood cell
Session topic: Publication Only
Abstract: PB2012
Type: Publication Only
Background
“What we call progress is the replacement of one trouble to another”,H.Ellis. Modern technologies that enabling blood transfusion even in utero, possibilities to identify new viruses and so on that is a background why doctors have to solve previously never-existing problems.Transient aplasia crisis is an often situation for the pediatric hematologist in Russia. It would seems strange, but we have decided to unite under this name two quite different nosological forms:hemolytic disease of the newborn,complicated with an absence of reticulocytosis, and transient erythroblastopenia of childhood.
Aims
To analyze the clinical features and management of aplasia crisis in children with hemolytic disease of newborns, complicated with an absence of reticulocytosis and children with transient erythroblastopenia.
Methods
There were reviewed medical histories of 62 patients (16 babies with hemolytic disease of the newborn, complicated absence of reticulocytosis, 46 children with transient erythroblastopenia of childhood). We have evaluated duration of hospitalization, number of transfusions,the connection of the disease with infection, therapeutic options. Period of evaluation was since 2009 to 2014 years.
Results
Children with hemolytic disease of the newborn were aged from 0 to 3. Children with transient erythroblastopenia of childhood were aged from 12 months to 5 years.The length of hospitalization of children ranged from 16 days to 35 days, the average was 24 days, and from 9 to 25 days on average 16 days, respectively.Children with hemolytic disease of the newborn were closely observed immediately after birth, and were admitted to hospital in adequate time. Only 12 of the 46 children with transient erythroblastopenia of childhood were applied to hospital immediately after infection. During the observation period the number of patients with transient erythroblastopenia of childhood increased from 7 (2009) to 15 (2014).Children with hemolytic disease of the newborn has increased from 3 (2009) to 5 (2014).6 children with hemolytic disease of the newborn required intrauterine transfusions, 9 children required exchange transfusion immediately after birth, 12 babies needed transfusion during the first month of life.There were 21 child with transient erythroblastopenia of childhood that required blood transfusions because of the hemic hypoxia signs.In 18 children with transient erythroblastopenia of childhood was verified acute viral infection (6 EBV,2 Parvovirus 19,4 CMV, 5 herpes virus type 6,1 herpes type 1).In children with hemolytic disease of the newborn, complicated by aplastic crisis, acute viral infections has not been found. Two children with severe long regenerating form of hemolytic disease of the newborn held a bone marrow biopsy, to 44 patients with erythroblastopenia was also made this study.According to the results of myelogram in all patients there was excluded systemic blood diseases. All patients with hemolytic disease of the newborn received drugs of erythropoietin from 5 to 15 injections depending on the severity of the condition . Reticulocytosis crisis was reached in an average of 4-5 injections. All patients with erythroblastopenia received B group vitamins, 16 children received a course of prednisolone. Children with erythroblastopenia had normalization of blood count at 12-25 day.
Summary
Transient aplasia crisis, that presented by normochromic aregenerating anemia, is severe, but in the modern world, treatable condition. Duration and severity of hemolytic disease of the newborn regenerating status is determined by prenatal transfusion therapy. Severity and length of transient erythroblastopenia of childhood is determined by the etiology of the infectious agent and the time of anemia status. Parvovirus B19 is not the only reason for the erythroblastopenia of childhood.Both of these diseases are relatively benign conditions, it can pass without trace, but in view of the high transfusion dependence it requires further study and observation. Regularly blood tests after birth and diseases can help to find this conditions earlier and to reduce transfusion rate.
Keyword(s): Bone Marrow, Red blood cell
Session topic: Publication Only
Type: Publication Only
Background
“What we call progress is the replacement of one trouble to another”,H.Ellis. Modern technologies that enabling blood transfusion even in utero, possibilities to identify new viruses and so on that is a background why doctors have to solve previously never-existing problems.Transient aplasia crisis is an often situation for the pediatric hematologist in Russia. It would seems strange, but we have decided to unite under this name two quite different nosological forms:hemolytic disease of the newborn,complicated with an absence of reticulocytosis, and transient erythroblastopenia of childhood.
Aims
To analyze the clinical features and management of aplasia crisis in children with hemolytic disease of newborns, complicated with an absence of reticulocytosis and children with transient erythroblastopenia.
Methods
There were reviewed medical histories of 62 patients (16 babies with hemolytic disease of the newborn, complicated absence of reticulocytosis, 46 children with transient erythroblastopenia of childhood). We have evaluated duration of hospitalization, number of transfusions,the connection of the disease with infection, therapeutic options. Period of evaluation was since 2009 to 2014 years.
Results
Children with hemolytic disease of the newborn were aged from 0 to 3. Children with transient erythroblastopenia of childhood were aged from 12 months to 5 years.The length of hospitalization of children ranged from 16 days to 35 days, the average was 24 days, and from 9 to 25 days on average 16 days, respectively.Children with hemolytic disease of the newborn were closely observed immediately after birth, and were admitted to hospital in adequate time. Only 12 of the 46 children with transient erythroblastopenia of childhood were applied to hospital immediately after infection. During the observation period the number of patients with transient erythroblastopenia of childhood increased from 7 (2009) to 15 (2014).Children with hemolytic disease of the newborn has increased from 3 (2009) to 5 (2014).6 children with hemolytic disease of the newborn required intrauterine transfusions, 9 children required exchange transfusion immediately after birth, 12 babies needed transfusion during the first month of life.There were 21 child with transient erythroblastopenia of childhood that required blood transfusions because of the hemic hypoxia signs.In 18 children with transient erythroblastopenia of childhood was verified acute viral infection (6 EBV,2 Parvovirus 19,4 CMV, 5 herpes virus type 6,1 herpes type 1).In children with hemolytic disease of the newborn, complicated by aplastic crisis, acute viral infections has not been found. Two children with severe long regenerating form of hemolytic disease of the newborn held a bone marrow biopsy, to 44 patients with erythroblastopenia was also made this study.According to the results of myelogram in all patients there was excluded systemic blood diseases. All patients with hemolytic disease of the newborn received drugs of erythropoietin from 5 to 15 injections depending on the severity of the condition . Reticulocytosis crisis was reached in an average of 4-5 injections. All patients with erythroblastopenia received B group vitamins, 16 children received a course of prednisolone. Children with erythroblastopenia had normalization of blood count at 12-25 day.
Summary
Transient aplasia crisis, that presented by normochromic aregenerating anemia, is severe, but in the modern world, treatable condition. Duration and severity of hemolytic disease of the newborn regenerating status is determined by prenatal transfusion therapy. Severity and length of transient erythroblastopenia of childhood is determined by the etiology of the infectious agent and the time of anemia status. Parvovirus B19 is not the only reason for the erythroblastopenia of childhood.Both of these diseases are relatively benign conditions, it can pass without trace, but in view of the high transfusion dependence it requires further study and observation. Regularly blood tests after birth and diseases can help to find this conditions earlier and to reduce transfusion rate.
Keyword(s): Bone Marrow, Red blood cell
Session topic: Publication Only
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