Pediatric Hematology and Oncology
Contributions
Type: Publication Only
Background
BACKGROUND: Iron is clearly important for brain development as well as for prevention of anemia, and more study is warranted to understand its role in these common neurodevelopmental disorders .Iron deficiency has also been associated with alterations in synaptic neurotransmitter systems including norepinephrine, dopamine, serotonin, glutamate and gamma-aminobutyric acid (GABA). Febrile seizures may reflect different facets of altered brain excitability that is enhanced by iron deficiency and also influenced by genetic factors.
Aims
OBJECTIVE: To find the association between iron deficiency anemia and febrile convulsions among children aged 6 to 36 months presenting at Pediatric Hematology and Oncology out patients clinic of Zagazig university hospital- Zagazig city – Egypt, from January 20011 to December 20014. .As well as to find characteristics of febrile convulsion with iron deficiency in Pediatrics.
Methods
PATIENTS AND METHODS: A total of 200 patients fulfilled the study criteria of febrile seizure and 100 patients with any febrile illness without convulsion. These were divided into two groups with children having febrile seizures comprised the cases (Group I) while those having only febrile illness with no seizures comprised the controls (Group II). Both matched for age and gender. Workup for seizures [ History and complete neurological and developmental examination .EEG and MRI according the need for each case] and iron deficiency anemia [ CBC- Serum iron – Serum Ferritin- Total Protein Iron Binding Capacity – Serum Calcium ionized and total ] were done and data was analyzed using SPSS version 10. According to iron deficiency, Group I had been subclassified into Group IA with iron deficiency and Group IB without iron deficiency. Any case with abnormal calcium level and those with MRI findings were excluded.
Results
RESULTS: A total of 24% of group I had iron deficiency (ID) and 16% had iron deficiency anemia (IDA), compared to 17% and 12% of controls respectively. There was significant decrease of Hb level, serum iron, serum ferritin and total iron binding capacity in children with febrile convulsion than that of controls. There was significant decrease age, HB conc, serum iron, ferritin and total protein iron binding capacity in group IA than group IB. One attack of febrile convulsion at presentation was significant higher in group IA than group IB. Duration of convulsion was significantly lower in group IA than group IB.
Summary
CONCLUSION:
Serum Iron, Total Protein Iron binding capacity and Plasma ferritin level were significantly lower in cases as compared to controls suggesting that iron deficient children are more prone to febrile seizures. The characteristics of iron deficiency related febrile convulsions were young age [9-21 month], short duration [not exceed 3 minutes],usually first attack,high with non-breast fed baby .
Session topic: Publication Only
Type: Publication Only
Background
BACKGROUND: Iron is clearly important for brain development as well as for prevention of anemia, and more study is warranted to understand its role in these common neurodevelopmental disorders .Iron deficiency has also been associated with alterations in synaptic neurotransmitter systems including norepinephrine, dopamine, serotonin, glutamate and gamma-aminobutyric acid (GABA). Febrile seizures may reflect different facets of altered brain excitability that is enhanced by iron deficiency and also influenced by genetic factors.
Aims
OBJECTIVE: To find the association between iron deficiency anemia and febrile convulsions among children aged 6 to 36 months presenting at Pediatric Hematology and Oncology out patients clinic of Zagazig university hospital- Zagazig city – Egypt, from January 20011 to December 20014. .As well as to find characteristics of febrile convulsion with iron deficiency in Pediatrics.
Methods
PATIENTS AND METHODS: A total of 200 patients fulfilled the study criteria of febrile seizure and 100 patients with any febrile illness without convulsion. These were divided into two groups with children having febrile seizures comprised the cases (Group I) while those having only febrile illness with no seizures comprised the controls (Group II). Both matched for age and gender. Workup for seizures [ History and complete neurological and developmental examination .EEG and MRI according the need for each case] and iron deficiency anemia [ CBC- Serum iron – Serum Ferritin- Total Protein Iron Binding Capacity – Serum Calcium ionized and total ] were done and data was analyzed using SPSS version 10. According to iron deficiency, Group I had been subclassified into Group IA with iron deficiency and Group IB without iron deficiency. Any case with abnormal calcium level and those with MRI findings were excluded.
Results
RESULTS: A total of 24% of group I had iron deficiency (ID) and 16% had iron deficiency anemia (IDA), compared to 17% and 12% of controls respectively. There was significant decrease of Hb level, serum iron, serum ferritin and total iron binding capacity in children with febrile convulsion than that of controls. There was significant decrease age, HB conc, serum iron, ferritin and total protein iron binding capacity in group IA than group IB. One attack of febrile convulsion at presentation was significant higher in group IA than group IB. Duration of convulsion was significantly lower in group IA than group IB.
Summary
CONCLUSION:
Serum Iron, Total Protein Iron binding capacity and Plasma ferritin level were significantly lower in cases as compared to controls suggesting that iron deficient children are more prone to febrile seizures. The characteristics of iron deficiency related febrile convulsions were young age [9-21 month], short duration [not exceed 3 minutes],usually first attack,high with non-breast fed baby .
Session topic: Publication Only