IMPACT OF PG-SGA SCORE ON SURVIVAL IN PATIENTS WITH MULTIPLE MYELOMA
(Abstract release date: 05/21/15)
EHA Library. Kim H. 06/12/15; 102759; PB1868
Disclosure(s): Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Hematology-Oncology, Department of Medicine
Hae Su Kim
Contributions
Contributions
Abstract
Abstract: PB1868
Type: Publication Only
Background
Disease-related weight loss is relatively common in patients with newly diagnosed multiple myeloma, but there are limited data on the impact of nutritional status on survival.
Aims
Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we retrospectively explored the effect of malnutrition on the survival of multiple myeloma patients. We also investigated the relationship between PG-SGA score prior to chemotherapy and clinical manifestation, in patients with multiple myeloma.
Methods
Analysis was performed on a retrospectively assembled cohort of 216 multiple myeloma patients diagnosed between October 1, 2002, and October 31, 2013. A total of 216 myeloma patients were subdivided into three groups based on PG-SGA scores.
Results
Twenty-three percent (50/216) patients had a PG-SGA score 9 or over, indicating severe malnutrition requiring specialist nutrition intervention. BMI and serum LDH were independently associated with PG-SGA scores (p<0.05). The median survival times were not reached in nourished patients with PG-SGA score 0-3, 58.7 months in moderately malnourished patients with PG-SGA score 4-8 and 35.0 months in severely malnourished patients with PG-SGA score ≥9 (p=0.001). Multivariate analysis showed that PG-SGA score ≥9 patients compared with PG-SGA score 0-3 patients (HR 2.347, 95 % confidence interval [CI] 1.271-4.334; p=0.006), International Staging System (ISS) stage III compared with ISS stage I (HR 2.360, 95 % CI 1.271-4.379, p=0.007) and autologous stem cell transplantation (HR 0.388, 95 % CI 0.248-0.606, p<0.001) were associated with overall survival.
Summary
In conclusion, higher PG-SGA score prior to chemotherapy was associated with reduced survival among patients with multiple myeloma. Nutritional evaluation should be integral part of the clinical assessment of MM patients and PG-SGA score would be an appropriate tool to evaluate nutritional status.
Keyword(s): Multiple myeloma, Prognosis
Type: Publication Only
Background
Disease-related weight loss is relatively common in patients with newly diagnosed multiple myeloma, but there are limited data on the impact of nutritional status on survival.
Aims
Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we retrospectively explored the effect of malnutrition on the survival of multiple myeloma patients. We also investigated the relationship between PG-SGA score prior to chemotherapy and clinical manifestation, in patients with multiple myeloma.
Methods
Analysis was performed on a retrospectively assembled cohort of 216 multiple myeloma patients diagnosed between October 1, 2002, and October 31, 2013. A total of 216 myeloma patients were subdivided into three groups based on PG-SGA scores.
Results
Twenty-three percent (50/216) patients had a PG-SGA score 9 or over, indicating severe malnutrition requiring specialist nutrition intervention. BMI and serum LDH were independently associated with PG-SGA scores (p<0.05). The median survival times were not reached in nourished patients with PG-SGA score 0-3, 58.7 months in moderately malnourished patients with PG-SGA score 4-8 and 35.0 months in severely malnourished patients with PG-SGA score ≥9 (p=0.001). Multivariate analysis showed that PG-SGA score ≥9 patients compared with PG-SGA score 0-3 patients (HR 2.347, 95 % confidence interval [CI] 1.271-4.334; p=0.006), International Staging System (ISS) stage III compared with ISS stage I (HR 2.360, 95 % CI 1.271-4.379, p=0.007) and autologous stem cell transplantation (HR 0.388, 95 % CI 0.248-0.606, p<0.001) were associated with overall survival.
Summary
In conclusion, higher PG-SGA score prior to chemotherapy was associated with reduced survival among patients with multiple myeloma. Nutritional evaluation should be integral part of the clinical assessment of MM patients and PG-SGA score would be an appropriate tool to evaluate nutritional status.
Keyword(s): Multiple myeloma, Prognosis
Abstract: PB1868
Type: Publication Only
Background
Disease-related weight loss is relatively common in patients with newly diagnosed multiple myeloma, but there are limited data on the impact of nutritional status on survival.
Aims
Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we retrospectively explored the effect of malnutrition on the survival of multiple myeloma patients. We also investigated the relationship between PG-SGA score prior to chemotherapy and clinical manifestation, in patients with multiple myeloma.
Methods
Analysis was performed on a retrospectively assembled cohort of 216 multiple myeloma patients diagnosed between October 1, 2002, and October 31, 2013. A total of 216 myeloma patients were subdivided into three groups based on PG-SGA scores.
Results
Twenty-three percent (50/216) patients had a PG-SGA score 9 or over, indicating severe malnutrition requiring specialist nutrition intervention. BMI and serum LDH were independently associated with PG-SGA scores (p<0.05). The median survival times were not reached in nourished patients with PG-SGA score 0-3, 58.7 months in moderately malnourished patients with PG-SGA score 4-8 and 35.0 months in severely malnourished patients with PG-SGA score ≥9 (p=0.001). Multivariate analysis showed that PG-SGA score ≥9 patients compared with PG-SGA score 0-3 patients (HR 2.347, 95 % confidence interval [CI] 1.271-4.334; p=0.006), International Staging System (ISS) stage III compared with ISS stage I (HR 2.360, 95 % CI 1.271-4.379, p=0.007) and autologous stem cell transplantation (HR 0.388, 95 % CI 0.248-0.606, p<0.001) were associated with overall survival.
Summary
In conclusion, higher PG-SGA score prior to chemotherapy was associated with reduced survival among patients with multiple myeloma. Nutritional evaluation should be integral part of the clinical assessment of MM patients and PG-SGA score would be an appropriate tool to evaluate nutritional status.
Keyword(s): Multiple myeloma, Prognosis
Type: Publication Only
Background
Disease-related weight loss is relatively common in patients with newly diagnosed multiple myeloma, but there are limited data on the impact of nutritional status on survival.
Aims
Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we retrospectively explored the effect of malnutrition on the survival of multiple myeloma patients. We also investigated the relationship between PG-SGA score prior to chemotherapy and clinical manifestation, in patients with multiple myeloma.
Methods
Analysis was performed on a retrospectively assembled cohort of 216 multiple myeloma patients diagnosed between October 1, 2002, and October 31, 2013. A total of 216 myeloma patients were subdivided into three groups based on PG-SGA scores.
Results
Twenty-three percent (50/216) patients had a PG-SGA score 9 or over, indicating severe malnutrition requiring specialist nutrition intervention. BMI and serum LDH were independently associated with PG-SGA scores (p<0.05). The median survival times were not reached in nourished patients with PG-SGA score 0-3, 58.7 months in moderately malnourished patients with PG-SGA score 4-8 and 35.0 months in severely malnourished patients with PG-SGA score ≥9 (p=0.001). Multivariate analysis showed that PG-SGA score ≥9 patients compared with PG-SGA score 0-3 patients (HR 2.347, 95 % confidence interval [CI] 1.271-4.334; p=0.006), International Staging System (ISS) stage III compared with ISS stage I (HR 2.360, 95 % CI 1.271-4.379, p=0.007) and autologous stem cell transplantation (HR 0.388, 95 % CI 0.248-0.606, p<0.001) were associated with overall survival.
Summary
In conclusion, higher PG-SGA score prior to chemotherapy was associated with reduced survival among patients with multiple myeloma. Nutritional evaluation should be integral part of the clinical assessment of MM patients and PG-SGA score would be an appropriate tool to evaluate nutritional status.
Keyword(s): Multiple myeloma, Prognosis
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