Contributions
Type: Publication Only
Background
We evaluated responsiveness to parenteral Iron therapy in the differential diagnosis
from unexplained refractory iron deficiency anemia to iron-refractory iron deficiency anemia .
Aims
We evaluated responsiveness to parenteral Iron therapy in the differential diagnosis
from unexplained refractory iron deficiency anemia to iron-refractory iron deficiency anemia .
Methods
This study analyzed responses to IV iron sucrose therapy given to 15 children with unexplained refractory IDA who were unresponsive to oral iron therapy.
Results
Ferritin, MCV, MCH and Hb values were normal range in 10 patients at 6 weeks following the first therapy. The increase in Hb, MCH, MCV, and ferritin values were ranging from 2.6 to 3.5g/dL, 1.7 to 4.2 pg, 2 to 9 fL and 13 to 25 ng/ml in table 1, respectively.
In five patients, Hb, MCH and MCV mean (range) values [11.2 g/dL (11-12.2), 24.5 pg (24-25.6) and 67fL (65-70)] were nearly normal but ferritin mean (range) values [ 9.8 ng/ml (8-11)] were below normal. The increase in Hb, MCH, MCV and ferritin were ranging from 2.6 to 3.5g/dL,7 to 4.2 pg, 2 to 9 fL and 5 to 12 ng/ml, respectively. Children with IRIDA in previous our study, Hb, MCH, MCV and ferritin values increased 6 weeks after the first therapy. The increase in Hb was 0.8–2.7g/dL and that of MCH, MCV, and ferritin values were 1.7–4.2 pg, 2–9 fL, and 13–25 ng/mL, respectively.
Summary
Intravenous iron therapy increased rapidly blood parameters in children with unexplained refractory IDA. The hematologic response to IV iron therapy should be used differentiation from unexplained refractory IDA to IRIDA.
Type: Publication Only
Background
We evaluated responsiveness to parenteral Iron therapy in the differential diagnosis
from unexplained refractory iron deficiency anemia to iron-refractory iron deficiency anemia .
Aims
We evaluated responsiveness to parenteral Iron therapy in the differential diagnosis
from unexplained refractory iron deficiency anemia to iron-refractory iron deficiency anemia .
Methods
This study analyzed responses to IV iron sucrose therapy given to 15 children with unexplained refractory IDA who were unresponsive to oral iron therapy.
Results
Ferritin, MCV, MCH and Hb values were normal range in 10 patients at 6 weeks following the first therapy. The increase in Hb, MCH, MCV, and ferritin values were ranging from 2.6 to 3.5g/dL, 1.7 to 4.2 pg, 2 to 9 fL and 13 to 25 ng/ml in table 1, respectively.
In five patients, Hb, MCH and MCV mean (range) values [11.2 g/dL (11-12.2), 24.5 pg (24-25.6) and 67fL (65-70)] were nearly normal but ferritin mean (range) values [ 9.8 ng/ml (8-11)] were below normal. The increase in Hb, MCH, MCV and ferritin were ranging from 2.6 to 3.5g/dL,7 to 4.2 pg, 2 to 9 fL and 5 to 12 ng/ml, respectively. Children with IRIDA in previous our study, Hb, MCH, MCV and ferritin values increased 6 weeks after the first therapy. The increase in Hb was 0.8–2.7g/dL and that of MCH, MCV, and ferritin values were 1.7–4.2 pg, 2–9 fL, and 13–25 ng/mL, respectively.
Summary
Intravenous iron therapy increased rapidly blood parameters in children with unexplained refractory IDA. The hematologic response to IV iron therapy should be used differentiation from unexplained refractory IDA to IRIDA.