SIMILAR EPIDEMIOLOGICAL TRENDS OF LYMPHOID MALIGNANCIES AND THEIR RESPECTIVE PRECURSOR LESIONS IN TAIWAN
(Abstract release date: 05/21/15)
EHA Library. Hsieh P. 06/12/15; 102663; PB1715
Disclosure(s): Far Eastern Memorial Hospital
Pei-Ying Hsieh
Contributions
Contributions
Abstract
Abstract: PB1715
Type: Publication Only
Background
Based on epidemiological studies, it is well known that Taiwan differs from the Western countries in terms of incidence of lymphoid malignancies with follicular lymphoma (FL), multiple myeloma (MM), and chronic lymphocytic leukemia (CLL) being much less prevalent The respective incidence rates are around one-fourth, one-third, and one-sixth of the one in the US. For these reasons, it is of interest to evaluate whether also their respective precursor conditions, i.e., circulating t(14;18)-IGH/BCL2 translocation, monoclonal gammopathy of unknown significance (MGUS), and monoclonal B-cell lymphocytosis (MBL) are also less common in Taiwan.
Aims
To know the epidemiology of the preursor conditions of lymphoid malignancies in Taiwan.
Methods
We screened 300 healthy Taiwanese individuals with the median age of 43 (range 23~73) for the presence of IGH/BCL2 translocation in peripheral blood mononuclear cells by polymerase chain reaction. In another cohort of 302 healthy individuals with the median age of 53 (range 23-79), the screening for the appearance of MGUS by serum immunofixation and MBL by flow cytometry were done. The results were compared to the data from Western cohorts.
Results
In line with the epidemiological findings on the actual diseases, the prevalence rates of all three precursor conditions appear significantly lower in the Taiwanese population with 10.7% (32/300) of the cases positive for circulating IGH/BCL-2 translocations, 1.3% (4/302) positive for MGUS, and 1.3% (4/302) positive for MBL, as compared with the frequencies of more than 50% for circulating IGH/BCL-2 translocation, 3~5% for MGUS, and 3.5~7% for MBL in the Western populations. The differences, however, were similar to those observed for the incidence rates of FL, MM, and CLL, respectively, between Taiwan and the West. For MGUS and MBL, the numbers of positive cases were too small for analyses in terms of age. In the case of circulating IGH/BCL2 translocations, the prevalence in the healthy population was higher in middle-aged to older people than in young adults (6.3% in the 3rd decade, 6.6% in the 4th decade, 13.8% in the 5th decade and 10.6% in the 6th decade), similar to the age-distribution pattern of FL.
Summary
The present study demonstrates lower rates for pre-neoplastic conditions in the Taiwanese population, i.e. of the presence of the circulating t(14;18)-IGH/BCL2 translocations, MGUS, and MBL that is in line with the known lower frequency of their respective lymphoid neoplasms as compared to Western populations. These results confirm the role of the precursor conditions during the natural history of the actual diseases and the pre-neoplastic nature of these manifestations. Unraveling the molecular and genetic features of circulating IGH/BCL2 translocations, MGUS, and MBL in healthy Taiwanese population will be key to understand the pathogenetic mechanisms responsible for the lower frequencies of FL, MM, and CLL as compared to the Western populations.
Keyword(s): Chronic lymphocytic leukemia
Type: Publication Only
Background
Based on epidemiological studies, it is well known that Taiwan differs from the Western countries in terms of incidence of lymphoid malignancies with follicular lymphoma (FL), multiple myeloma (MM), and chronic lymphocytic leukemia (CLL) being much less prevalent The respective incidence rates are around one-fourth, one-third, and one-sixth of the one in the US. For these reasons, it is of interest to evaluate whether also their respective precursor conditions, i.e., circulating t(14;18)-IGH/BCL2 translocation, monoclonal gammopathy of unknown significance (MGUS), and monoclonal B-cell lymphocytosis (MBL) are also less common in Taiwan.
Aims
To know the epidemiology of the preursor conditions of lymphoid malignancies in Taiwan.
Methods
We screened 300 healthy Taiwanese individuals with the median age of 43 (range 23~73) for the presence of IGH/BCL2 translocation in peripheral blood mononuclear cells by polymerase chain reaction. In another cohort of 302 healthy individuals with the median age of 53 (range 23-79), the screening for the appearance of MGUS by serum immunofixation and MBL by flow cytometry were done. The results were compared to the data from Western cohorts.
Results
In line with the epidemiological findings on the actual diseases, the prevalence rates of all three precursor conditions appear significantly lower in the Taiwanese population with 10.7% (32/300) of the cases positive for circulating IGH/BCL-2 translocations, 1.3% (4/302) positive for MGUS, and 1.3% (4/302) positive for MBL, as compared with the frequencies of more than 50% for circulating IGH/BCL-2 translocation, 3~5% for MGUS, and 3.5~7% for MBL in the Western populations. The differences, however, were similar to those observed for the incidence rates of FL, MM, and CLL, respectively, between Taiwan and the West. For MGUS and MBL, the numbers of positive cases were too small for analyses in terms of age. In the case of circulating IGH/BCL2 translocations, the prevalence in the healthy population was higher in middle-aged to older people than in young adults (6.3% in the 3rd decade, 6.6% in the 4th decade, 13.8% in the 5th decade and 10.6% in the 6th decade), similar to the age-distribution pattern of FL.
Summary
The present study demonstrates lower rates for pre-neoplastic conditions in the Taiwanese population, i.e. of the presence of the circulating t(14;18)-IGH/BCL2 translocations, MGUS, and MBL that is in line with the known lower frequency of their respective lymphoid neoplasms as compared to Western populations. These results confirm the role of the precursor conditions during the natural history of the actual diseases and the pre-neoplastic nature of these manifestations. Unraveling the molecular and genetic features of circulating IGH/BCL2 translocations, MGUS, and MBL in healthy Taiwanese population will be key to understand the pathogenetic mechanisms responsible for the lower frequencies of FL, MM, and CLL as compared to the Western populations.
Keyword(s): Chronic lymphocytic leukemia
Abstract: PB1715
Type: Publication Only
Background
Based on epidemiological studies, it is well known that Taiwan differs from the Western countries in terms of incidence of lymphoid malignancies with follicular lymphoma (FL), multiple myeloma (MM), and chronic lymphocytic leukemia (CLL) being much less prevalent The respective incidence rates are around one-fourth, one-third, and one-sixth of the one in the US. For these reasons, it is of interest to evaluate whether also their respective precursor conditions, i.e., circulating t(14;18)-IGH/BCL2 translocation, monoclonal gammopathy of unknown significance (MGUS), and monoclonal B-cell lymphocytosis (MBL) are also less common in Taiwan.
Aims
To know the epidemiology of the preursor conditions of lymphoid malignancies in Taiwan.
Methods
We screened 300 healthy Taiwanese individuals with the median age of 43 (range 23~73) for the presence of IGH/BCL2 translocation in peripheral blood mononuclear cells by polymerase chain reaction. In another cohort of 302 healthy individuals with the median age of 53 (range 23-79), the screening for the appearance of MGUS by serum immunofixation and MBL by flow cytometry were done. The results were compared to the data from Western cohorts.
Results
In line with the epidemiological findings on the actual diseases, the prevalence rates of all three precursor conditions appear significantly lower in the Taiwanese population with 10.7% (32/300) of the cases positive for circulating IGH/BCL-2 translocations, 1.3% (4/302) positive for MGUS, and 1.3% (4/302) positive for MBL, as compared with the frequencies of more than 50% for circulating IGH/BCL-2 translocation, 3~5% for MGUS, and 3.5~7% for MBL in the Western populations. The differences, however, were similar to those observed for the incidence rates of FL, MM, and CLL, respectively, between Taiwan and the West. For MGUS and MBL, the numbers of positive cases were too small for analyses in terms of age. In the case of circulating IGH/BCL2 translocations, the prevalence in the healthy population was higher in middle-aged to older people than in young adults (6.3% in the 3rd decade, 6.6% in the 4th decade, 13.8% in the 5th decade and 10.6% in the 6th decade), similar to the age-distribution pattern of FL.
Summary
The present study demonstrates lower rates for pre-neoplastic conditions in the Taiwanese population, i.e. of the presence of the circulating t(14;18)-IGH/BCL2 translocations, MGUS, and MBL that is in line with the known lower frequency of their respective lymphoid neoplasms as compared to Western populations. These results confirm the role of the precursor conditions during the natural history of the actual diseases and the pre-neoplastic nature of these manifestations. Unraveling the molecular and genetic features of circulating IGH/BCL2 translocations, MGUS, and MBL in healthy Taiwanese population will be key to understand the pathogenetic mechanisms responsible for the lower frequencies of FL, MM, and CLL as compared to the Western populations.
Keyword(s): Chronic lymphocytic leukemia
Type: Publication Only
Background
Based on epidemiological studies, it is well known that Taiwan differs from the Western countries in terms of incidence of lymphoid malignancies with follicular lymphoma (FL), multiple myeloma (MM), and chronic lymphocytic leukemia (CLL) being much less prevalent The respective incidence rates are around one-fourth, one-third, and one-sixth of the one in the US. For these reasons, it is of interest to evaluate whether also their respective precursor conditions, i.e., circulating t(14;18)-IGH/BCL2 translocation, monoclonal gammopathy of unknown significance (MGUS), and monoclonal B-cell lymphocytosis (MBL) are also less common in Taiwan.
Aims
To know the epidemiology of the preursor conditions of lymphoid malignancies in Taiwan.
Methods
We screened 300 healthy Taiwanese individuals with the median age of 43 (range 23~73) for the presence of IGH/BCL2 translocation in peripheral blood mononuclear cells by polymerase chain reaction. In another cohort of 302 healthy individuals with the median age of 53 (range 23-79), the screening for the appearance of MGUS by serum immunofixation and MBL by flow cytometry were done. The results were compared to the data from Western cohorts.
Results
In line with the epidemiological findings on the actual diseases, the prevalence rates of all three precursor conditions appear significantly lower in the Taiwanese population with 10.7% (32/300) of the cases positive for circulating IGH/BCL-2 translocations, 1.3% (4/302) positive for MGUS, and 1.3% (4/302) positive for MBL, as compared with the frequencies of more than 50% for circulating IGH/BCL-2 translocation, 3~5% for MGUS, and 3.5~7% for MBL in the Western populations. The differences, however, were similar to those observed for the incidence rates of FL, MM, and CLL, respectively, between Taiwan and the West. For MGUS and MBL, the numbers of positive cases were too small for analyses in terms of age. In the case of circulating IGH/BCL2 translocations, the prevalence in the healthy population was higher in middle-aged to older people than in young adults (6.3% in the 3rd decade, 6.6% in the 4th decade, 13.8% in the 5th decade and 10.6% in the 6th decade), similar to the age-distribution pattern of FL.
Summary
The present study demonstrates lower rates for pre-neoplastic conditions in the Taiwanese population, i.e. of the presence of the circulating t(14;18)-IGH/BCL2 translocations, MGUS, and MBL that is in line with the known lower frequency of their respective lymphoid neoplasms as compared to Western populations. These results confirm the role of the precursor conditions during the natural history of the actual diseases and the pre-neoplastic nature of these manifestations. Unraveling the molecular and genetic features of circulating IGH/BCL2 translocations, MGUS, and MBL in healthy Taiwanese population will be key to understand the pathogenetic mechanisms responsible for the lower frequencies of FL, MM, and CLL as compared to the Western populations.
Keyword(s): Chronic lymphocytic leukemia
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