IMPACT OF PLATELETS ALLOIMMUNIZATION IN ALLOGRAFT
(Abstract release date: 05/21/15)
EHA Library. Eddou H. 06/12/15; 102629; PB2024
Disclosure(s): Hôpital Militaire d’Instruction Mohammed V, Rabat, MarocService d’Hématologie Clinique,
Hicham Eddou
Contributions
Contributions
Abstract
Abstract: PB2024
Type: Publication Only
Background
The prolonged thrombocytopenia after hematopoietic stem cell transplantation (HSCT) present factor of poor prognosis. There causes are varied and complex; whose platelet alloimmunization, which is responsible for refractoriness platelet transfusions.
Aims
The objective is to demonstrate the impact of mismatches between donor and recipient for human platelet antigens (HPA) on recovery of platelet counts after transplantation.
Methods
A retrospective analysis of 96 patients transplanted at the Department Hematology at Hospital Henri Mondor, Creteil, between January 2011 and December 2013 was performed. Only geno and pheno-identical HSCT are studies.
Results
We tested each of the four HPA systems (HPA1, HPA3, HPA5 and HPA15), the platelet recovery in recipients 'aa' as they receive HSC donor 'aa' or 'ab or bb'. We demonstrated no significant differences between groups with or no mismatch HPA, compared at 1, 3, 6, and 12 months after graft. While there was a trend (P = 0.07) in HPA3 system at 24 months to transplant. In HPA5 system, the differences were in the expected direction without statistically significant.
Summary
It would be important to demonstrate the impact of mismatch HPA on platelet recovery in a most important sample of patients to prevent the onset of refractoriness to platelet transfusions in the course of allogeneic haematopoietic stem cell.
Session topic: Publication Only
Type: Publication Only
Background
The prolonged thrombocytopenia after hematopoietic stem cell transplantation (HSCT) present factor of poor prognosis. There causes are varied and complex; whose platelet alloimmunization, which is responsible for refractoriness platelet transfusions.
Aims
The objective is to demonstrate the impact of mismatches between donor and recipient for human platelet antigens (HPA) on recovery of platelet counts after transplantation.
Methods
A retrospective analysis of 96 patients transplanted at the Department Hematology at Hospital Henri Mondor, Creteil, between January 2011 and December 2013 was performed. Only geno and pheno-identical HSCT are studies.
Results
We tested each of the four HPA systems (HPA1, HPA3, HPA5 and HPA15), the platelet recovery in recipients 'aa' as they receive HSC donor 'aa' or 'ab or bb'. We demonstrated no significant differences between groups with or no mismatch HPA, compared at 1, 3, 6, and 12 months after graft. While there was a trend (P = 0.07) in HPA3 system at 24 months to transplant. In HPA5 system, the differences were in the expected direction without statistically significant.
Summary
It would be important to demonstrate the impact of mismatch HPA on platelet recovery in a most important sample of patients to prevent the onset of refractoriness to platelet transfusions in the course of allogeneic haematopoietic stem cell.
Session topic: Publication Only
Abstract: PB2024
Type: Publication Only
Background
The prolonged thrombocytopenia after hematopoietic stem cell transplantation (HSCT) present factor of poor prognosis. There causes are varied and complex; whose platelet alloimmunization, which is responsible for refractoriness platelet transfusions.
Aims
The objective is to demonstrate the impact of mismatches between donor and recipient for human platelet antigens (HPA) on recovery of platelet counts after transplantation.
Methods
A retrospective analysis of 96 patients transplanted at the Department Hematology at Hospital Henri Mondor, Creteil, between January 2011 and December 2013 was performed. Only geno and pheno-identical HSCT are studies.
Results
We tested each of the four HPA systems (HPA1, HPA3, HPA5 and HPA15), the platelet recovery in recipients 'aa' as they receive HSC donor 'aa' or 'ab or bb'. We demonstrated no significant differences between groups with or no mismatch HPA, compared at 1, 3, 6, and 12 months after graft. While there was a trend (P = 0.07) in HPA3 system at 24 months to transplant. In HPA5 system, the differences were in the expected direction without statistically significant.
Summary
It would be important to demonstrate the impact of mismatch HPA on platelet recovery in a most important sample of patients to prevent the onset of refractoriness to platelet transfusions in the course of allogeneic haematopoietic stem cell.
Session topic: Publication Only
Type: Publication Only
Background
The prolonged thrombocytopenia after hematopoietic stem cell transplantation (HSCT) present factor of poor prognosis. There causes are varied and complex; whose platelet alloimmunization, which is responsible for refractoriness platelet transfusions.
Aims
The objective is to demonstrate the impact of mismatches between donor and recipient for human platelet antigens (HPA) on recovery of platelet counts after transplantation.
Methods
A retrospective analysis of 96 patients transplanted at the Department Hematology at Hospital Henri Mondor, Creteil, between January 2011 and December 2013 was performed. Only geno and pheno-identical HSCT are studies.
Results
We tested each of the four HPA systems (HPA1, HPA3, HPA5 and HPA15), the platelet recovery in recipients 'aa' as they receive HSC donor 'aa' or 'ab or bb'. We demonstrated no significant differences between groups with or no mismatch HPA, compared at 1, 3, 6, and 12 months after graft. While there was a trend (P = 0.07) in HPA3 system at 24 months to transplant. In HPA5 system, the differences were in the expected direction without statistically significant.
Summary
It would be important to demonstrate the impact of mismatch HPA on platelet recovery in a most important sample of patients to prevent the onset of refractoriness to platelet transfusions in the course of allogeneic haematopoietic stem cell.
Session topic: Publication Only
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