IMPACT OF THE ABNORMALITIES IN IMMUNOGLOBULIN LEVELS IN THE EGYPTIAN PATIENTS WITH ITP
(Abstract release date: 05/21/15)
EHA Library. Abozied T. 06/12/15; 102627; PB1970
Disclosure(s): Mansoura oncology centerhematology
Tarek Abozied
Contributions
Contributions
Abstract
Abstract: PB1970
Type: Publication Only
Background
Key Words: ITP, Immunoglobulins
Correspondence to: Dr Tarek Aouzeid, Clinical Hematology Unit, Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
E-mail: drtarekaouzid@yahoo.com
Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that characterized mainly by a low platelet count and absence of any apparent initiating and/or underlying cause of the thrombocytopenia. ITP is associated with a loss of tolerance to platelet antigens and a phenotype of accelerated platelet destruction with impaired platelet production. Common variable immunodeficiency (CVID) is a mixed group of disorders characterized by decreasing the Immunoglobulins (Igs) and an increased susceptibility to repeated infections, autoimmunity and malignancies. Both ITP and autoimmune hemolytic anemia (AIHA) are autoimmune disorders which can be seen together with CVID
Aims
. This study aimed to assess the immune system deregulation in the form of measuring the immunoglobulins (Igs) levels in patients diagnosed as ITP and correlates the relation of these levels to the initial platelet counts, severity of the disease, treatment response and clinical outcome
Methods
. A
cross-section study was done on 105 patients’ age range from 10 - 61 years, with newly diagnosed ITP at the Oncology Center Mansoura University over the past 2 years
Results
The patients with IgA level below or equal to median had good response to stander treatment (steroids, intravenous Ig (IVIG), or intravenous anti-D), while the patients with a higher IgA level than median showed excellent response with stander treatment (P = 0.02). Subjects with High IgA levels associated with increased major bleeding but not platelet count. Low IgM levels associated with failure to response to stander treatment and platelet count but not major bleeding. Changes in IgG levels wasn’t associated with either response to treatment nor bleeding tendency or platelet count
Summary
. We recommend initial measure of immunoglobulin level in patients with ITP to help us in the treatment protocol for each patient.
Keyword(s): ITP
Type: Publication Only
Background
Key Words: ITP, Immunoglobulins
Correspondence to: Dr Tarek Aouzeid, Clinical Hematology Unit, Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
E-mail: drtarekaouzid@yahoo.com
Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that characterized mainly by a low platelet count and absence of any apparent initiating and/or underlying cause of the thrombocytopenia. ITP is associated with a loss of tolerance to platelet antigens and a phenotype of accelerated platelet destruction with impaired platelet production. Common variable immunodeficiency (CVID) is a mixed group of disorders characterized by decreasing the Immunoglobulins (Igs) and an increased susceptibility to repeated infections, autoimmunity and malignancies. Both ITP and autoimmune hemolytic anemia (AIHA) are autoimmune disorders which can be seen together with CVID
Aims
. This study aimed to assess the immune system deregulation in the form of measuring the immunoglobulins (Igs) levels in patients diagnosed as ITP and correlates the relation of these levels to the initial platelet counts, severity of the disease, treatment response and clinical outcome
Methods
. A
cross-section study was done on 105 patients’ age range from 10 - 61 years, with newly diagnosed ITP at the Oncology Center Mansoura University over the past 2 years
Results
The patients with IgA level below or equal to median had good response to stander treatment (steroids, intravenous Ig (IVIG), or intravenous anti-D), while the patients with a higher IgA level than median showed excellent response with stander treatment (P = 0.02). Subjects with High IgA levels associated with increased major bleeding but not platelet count. Low IgM levels associated with failure to response to stander treatment and platelet count but not major bleeding. Changes in IgG levels wasn’t associated with either response to treatment nor bleeding tendency or platelet count
Summary
. We recommend initial measure of immunoglobulin level in patients with ITP to help us in the treatment protocol for each patient.
Keyword(s): ITP
Abstract: PB1970
Type: Publication Only
Background
Key Words: ITP, Immunoglobulins
Correspondence to: Dr Tarek Aouzeid, Clinical Hematology Unit, Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
E-mail: drtarekaouzid@yahoo.com
Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that characterized mainly by a low platelet count and absence of any apparent initiating and/or underlying cause of the thrombocytopenia. ITP is associated with a loss of tolerance to platelet antigens and a phenotype of accelerated platelet destruction with impaired platelet production. Common variable immunodeficiency (CVID) is a mixed group of disorders characterized by decreasing the Immunoglobulins (Igs) and an increased susceptibility to repeated infections, autoimmunity and malignancies. Both ITP and autoimmune hemolytic anemia (AIHA) are autoimmune disorders which can be seen together with CVID
Aims
. This study aimed to assess the immune system deregulation in the form of measuring the immunoglobulins (Igs) levels in patients diagnosed as ITP and correlates the relation of these levels to the initial platelet counts, severity of the disease, treatment response and clinical outcome
Methods
. A
cross-section study was done on 105 patients’ age range from 10 - 61 years, with newly diagnosed ITP at the Oncology Center Mansoura University over the past 2 years
Results
The patients with IgA level below or equal to median had good response to stander treatment (steroids, intravenous Ig (IVIG), or intravenous anti-D), while the patients with a higher IgA level than median showed excellent response with stander treatment (P = 0.02). Subjects with High IgA levels associated with increased major bleeding but not platelet count. Low IgM levels associated with failure to response to stander treatment and platelet count but not major bleeding. Changes in IgG levels wasn’t associated with either response to treatment nor bleeding tendency or platelet count
Summary
. We recommend initial measure of immunoglobulin level in patients with ITP to help us in the treatment protocol for each patient.
Keyword(s): ITP
Type: Publication Only
Background
Key Words: ITP, Immunoglobulins
Correspondence to: Dr Tarek Aouzeid, Clinical Hematology Unit, Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
E-mail: drtarekaouzid@yahoo.com
Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that characterized mainly by a low platelet count and absence of any apparent initiating and/or underlying cause of the thrombocytopenia. ITP is associated with a loss of tolerance to platelet antigens and a phenotype of accelerated platelet destruction with impaired platelet production. Common variable immunodeficiency (CVID) is a mixed group of disorders characterized by decreasing the Immunoglobulins (Igs) and an increased susceptibility to repeated infections, autoimmunity and malignancies. Both ITP and autoimmune hemolytic anemia (AIHA) are autoimmune disorders which can be seen together with CVID
Aims
. This study aimed to assess the immune system deregulation in the form of measuring the immunoglobulins (Igs) levels in patients diagnosed as ITP and correlates the relation of these levels to the initial platelet counts, severity of the disease, treatment response and clinical outcome
Methods
. A
cross-section study was done on 105 patients’ age range from 10 - 61 years, with newly diagnosed ITP at the Oncology Center Mansoura University over the past 2 years
Results
The patients with IgA level below or equal to median had good response to stander treatment (steroids, intravenous Ig (IVIG), or intravenous anti-D), while the patients with a higher IgA level than median showed excellent response with stander treatment (P = 0.02). Subjects with High IgA levels associated with increased major bleeding but not platelet count. Low IgM levels associated with failure to response to stander treatment and platelet count but not major bleeding. Changes in IgG levels wasn’t associated with either response to treatment nor bleeding tendency or platelet count
Summary
. We recommend initial measure of immunoglobulin level in patients with ITP to help us in the treatment protocol for each patient.
Keyword(s): ITP
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