PREVELANCE OF H PYLORI INFECTION AND RISK OF GIT BLEEDING IN EGYPTIAN HAEMOPHILIC PATIENTS
(Abstract release date: 05/21/15)
EHA Library. el Husseiny N. 06/12/15; 102571; PB1694
Disclosure(s): Kaser El Eini UniversityHeamatology Department
Dr. Noha el Husseiny
Contributions
Contributions
Abstract
Abstract: PB1694
Type: Publication Only
Background
Aims
Aim of this study was to evaluate the prevalence of Helicobacter pylori infection in hemophilic patients, and to assess its impact on gastrointestinal bleeding associated with this infection in such patients.
Methods
Methods: we prospectively investigated the prevalence of H. pylori infection in 40 Egyptian patients with hemophilia A,B and von Willebrand syndrome and 20 male subjects were included. Every patient and control subject in the study was tested one time for H. pylori stool antigen by ELISA. All patients and control subjects were tested for occult blood using Guaiac-based fecal occult blood test.
Results
Results: Twenty eight out of 40 patients were H. pylori positive (70%); and 12 out of 20 control subjects were H. pylori positive (60%). The odds ratio is 1.55, 95% CI (0.6162 to 3.9269), Significance level P = 0.3497. Among 28 H.pylori positive patients, 5 patients tested positive for occult blood (17.9 %). Among the 12 H.pylori positive subjects in the control group, only one tested positive for occult blood (8.3%). Odds ratio for Occult bleeding in H pylori positive patients and control was 2.39: P= 0.4504. None of the H. pylori negative patients or control subjects had a positive occult blood disease.
Summary
Conclusion: We concluded that in patients with hemophilia, H. pylori should be considered as an important cause of GI bleeding. The recurrence of the infection and GI bleeding can be prevented with eradication of H. pylori. Screening test for H. pylori would be needed in patients with hemophilia in endemic areas.
Keyword(s): Helicobacter pylori, Hemophilia
Type: Publication Only
Background
: H pyelori is endemic in Egypt and present a main cause of gastrointestinal bleeding.
Aims
Aim of this study was to evaluate the prevalence of Helicobacter pylori infection in hemophilic patients, and to assess its impact on gastrointestinal bleeding associated with this infection in such patients.
Methods
Methods: we prospectively investigated the prevalence of H. pylori infection in 40 Egyptian patients with hemophilia A,B and von Willebrand syndrome and 20 male subjects were included. Every patient and control subject in the study was tested one time for H. pylori stool antigen by ELISA. All patients and control subjects were tested for occult blood using Guaiac-based fecal occult blood test.
Results
Results: Twenty eight out of 40 patients were H. pylori positive (70%); and 12 out of 20 control subjects were H. pylori positive (60%). The odds ratio is 1.55, 95% CI (0.6162 to 3.9269), Significance level P = 0.3497. Among 28 H.pylori positive patients, 5 patients tested positive for occult blood (17.9 %). Among the 12 H.pylori positive subjects in the control group, only one tested positive for occult blood (8.3%). Odds ratio for Occult bleeding in H pylori positive patients and control was 2.39: P= 0.4504. None of the H. pylori negative patients or control subjects had a positive occult blood disease.
Summary
Conclusion: We concluded that in patients with hemophilia, H. pylori should be considered as an important cause of GI bleeding. The recurrence of the infection and GI bleeding can be prevented with eradication of H. pylori. Screening test for H. pylori would be needed in patients with hemophilia in endemic areas.
Keyword(s): Helicobacter pylori, Hemophilia
Abstract: PB1694
Type: Publication Only
Background
Aims
Aim of this study was to evaluate the prevalence of Helicobacter pylori infection in hemophilic patients, and to assess its impact on gastrointestinal bleeding associated with this infection in such patients.
Methods
Methods: we prospectively investigated the prevalence of H. pylori infection in 40 Egyptian patients with hemophilia A,B and von Willebrand syndrome and 20 male subjects were included. Every patient and control subject in the study was tested one time for H. pylori stool antigen by ELISA. All patients and control subjects were tested for occult blood using Guaiac-based fecal occult blood test.
Results
Results: Twenty eight out of 40 patients were H. pylori positive (70%); and 12 out of 20 control subjects were H. pylori positive (60%). The odds ratio is 1.55, 95% CI (0.6162 to 3.9269), Significance level P = 0.3497. Among 28 H.pylori positive patients, 5 patients tested positive for occult blood (17.9 %). Among the 12 H.pylori positive subjects in the control group, only one tested positive for occult blood (8.3%). Odds ratio for Occult bleeding in H pylori positive patients and control was 2.39: P= 0.4504. None of the H. pylori negative patients or control subjects had a positive occult blood disease.
Summary
Conclusion: We concluded that in patients with hemophilia, H. pylori should be considered as an important cause of GI bleeding. The recurrence of the infection and GI bleeding can be prevented with eradication of H. pylori. Screening test for H. pylori would be needed in patients with hemophilia in endemic areas.
Keyword(s): Helicobacter pylori, Hemophilia
Type: Publication Only
Background
: H pyelori is endemic in Egypt and present a main cause of gastrointestinal bleeding.
Aims
Aim of this study was to evaluate the prevalence of Helicobacter pylori infection in hemophilic patients, and to assess its impact on gastrointestinal bleeding associated with this infection in such patients.
Methods
Methods: we prospectively investigated the prevalence of H. pylori infection in 40 Egyptian patients with hemophilia A,B and von Willebrand syndrome and 20 male subjects were included. Every patient and control subject in the study was tested one time for H. pylori stool antigen by ELISA. All patients and control subjects were tested for occult blood using Guaiac-based fecal occult blood test.
Results
Results: Twenty eight out of 40 patients were H. pylori positive (70%); and 12 out of 20 control subjects were H. pylori positive (60%). The odds ratio is 1.55, 95% CI (0.6162 to 3.9269), Significance level P = 0.3497. Among 28 H.pylori positive patients, 5 patients tested positive for occult blood (17.9 %). Among the 12 H.pylori positive subjects in the control group, only one tested positive for occult blood (8.3%). Odds ratio for Occult bleeding in H pylori positive patients and control was 2.39: P= 0.4504. None of the H. pylori negative patients or control subjects had a positive occult blood disease.
Summary
Conclusion: We concluded that in patients with hemophilia, H. pylori should be considered as an important cause of GI bleeding. The recurrence of the infection and GI bleeding can be prevented with eradication of H. pylori. Screening test for H. pylori would be needed in patients with hemophilia in endemic areas.
Keyword(s): Helicobacter pylori, Hemophilia
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