THE ROLE OF HLA HIGH RESOLUTION TYPING IN UMBILICAL CORD BLOOD TRANSPLANTATION
(Abstract release date: 05/21/15)
EHA Library. Sun A. 06/12/15; 102568; PB2026
Mr. Aining Sun
Contributions
Contributions
Abstract
Abstract: PB2026
Type: Publication Only
Background
Aims
To analyze HLA matching(low or high resolution ) on outcomes of umbilical cord blood transplantation(UCB) and the value of clinical application.
Methods
From October 2010 to July 2012,26 patients were selected umbilical cord blood transplantation in our hospital,in the absence of a suitable HLA-identical sibling donor or alternative donors.We examined the effects of HLA matching (low or high resolution ) on engraftment of leading, engraftment,graft-versus-host disease (GVHD), infection and mortality.Performed mainly by sequence-specific oligonucleotide probe (SSOP) methods, sequence-based typing (SBT) methods and high resolution sequence-specific primers(SSP) methods,retrospective HLA matching of cord blood,typed at high resolution for HLA-A,-B, -C, -DRB1, -DQ, and -DP and low resolution for HLA-A,B,DRB1.
Results
Compared single UBC units transplantation with double UBC units,the hematopoietic reconstitution rate was 88% vs 56%.The median total nucleated cells(TNC) of single and double cord blood was 5.5×107/kg, when TNC≥5×107/kg could promote neutrophil recoveries (p<0.05). The UBC units were a 6/10 HLA high resolution match or better with each other could promote UCB implantation advantaged?P<0.05?, accelerate platelet recovery?P<0.05?and reduce more risk of acute GVHD (grade III -IV)?P<0.05?.There are different between the group 5-6/6 HLA low resolution and 3-4/6 .but no statistical difference?P>0.05?.
Summary
The HLA High resolution typing can select the better UCB than HLA low-resoulution. It has important clinical value on promoting hematopoietic reconstitution and reducing complications after UCB transplation.
Keyword(s): Cord blood, HLA, Stem cell transplant
Session topic: Publication Only
Type: Publication Only
Background
1?s smdy was pur?10sed to investigate me clillical value of HLA mtchjn2(10w and tIigh I?esolution)aJldits effect on outcome of the patients received umbilical cord blood_?ransplantation(UCBT)?This study was purposed to investigate the clillical value of HLA matching(low and high resolution) and its effect on outcome of the patients received umbilical cord blood transplantation(UCBT)?
Aims
To analyze HLA matching(low or high resolution ) on outcomes of umbilical cord blood transplantation(UCB) and the value of clinical application.
Methods
From October 2010 to July 2012,26 patients were selected umbilical cord blood transplantation in our hospital,in the absence of a suitable HLA-identical sibling donor or alternative donors.We examined the effects of HLA matching (low or high resolution ) on engraftment of leading, engraftment,graft-versus-host disease (GVHD), infection and mortality.Performed mainly by sequence-specific oligonucleotide probe (SSOP) methods, sequence-based typing (SBT) methods and high resolution sequence-specific primers(SSP) methods,retrospective HLA matching of cord blood,typed at high resolution for HLA-A,-B, -C, -DRB1, -DQ, and -DP and low resolution for HLA-A,B,DRB1.
Results
Compared single UBC units transplantation with double UBC units,the hematopoietic reconstitution rate was 88% vs 56%.The median total nucleated cells(TNC) of single and double cord blood was 5.5×107/kg, when TNC≥5×107/kg could promote neutrophil recoveries (p<0.05). The UBC units were a 6/10 HLA high resolution match or better with each other could promote UCB implantation advantaged?P<0.05?, accelerate platelet recovery?P<0.05?and reduce more risk of acute GVHD (grade III -IV)?P<0.05?.There are different between the group 5-6/6 HLA low resolution and 3-4/6 .but no statistical difference?P>0.05?.
Summary
The HLA High resolution typing can select the better UCB than HLA low-resoulution. It has important clinical value on promoting hematopoietic reconstitution and reducing complications after UCB transplation.
Keyword(s): Cord blood, HLA, Stem cell transplant
Session topic: Publication Only
Abstract: PB2026
Type: Publication Only
Background
Aims
To analyze HLA matching(low or high resolution ) on outcomes of umbilical cord blood transplantation(UCB) and the value of clinical application.
Methods
From October 2010 to July 2012,26 patients were selected umbilical cord blood transplantation in our hospital,in the absence of a suitable HLA-identical sibling donor or alternative donors.We examined the effects of HLA matching (low or high resolution ) on engraftment of leading, engraftment,graft-versus-host disease (GVHD), infection and mortality.Performed mainly by sequence-specific oligonucleotide probe (SSOP) methods, sequence-based typing (SBT) methods and high resolution sequence-specific primers(SSP) methods,retrospective HLA matching of cord blood,typed at high resolution for HLA-A,-B, -C, -DRB1, -DQ, and -DP and low resolution for HLA-A,B,DRB1.
Results
Compared single UBC units transplantation with double UBC units,the hematopoietic reconstitution rate was 88% vs 56%.The median total nucleated cells(TNC) of single and double cord blood was 5.5×107/kg, when TNC≥5×107/kg could promote neutrophil recoveries (p<0.05). The UBC units were a 6/10 HLA high resolution match or better with each other could promote UCB implantation advantaged?P<0.05?, accelerate platelet recovery?P<0.05?and reduce more risk of acute GVHD (grade III -IV)?P<0.05?.There are different between the group 5-6/6 HLA low resolution and 3-4/6 .but no statistical difference?P>0.05?.
Summary
The HLA High resolution typing can select the better UCB than HLA low-resoulution. It has important clinical value on promoting hematopoietic reconstitution and reducing complications after UCB transplation.
Keyword(s): Cord blood, HLA, Stem cell transplant
Session topic: Publication Only
Type: Publication Only
Background
1?s smdy was pur?10sed to investigate me clillical value of HLA mtchjn2(10w and tIigh I?esolution)aJldits effect on outcome of the patients received umbilical cord blood_?ransplantation(UCBT)?This study was purposed to investigate the clillical value of HLA matching(low and high resolution) and its effect on outcome of the patients received umbilical cord blood transplantation(UCBT)?
Aims
To analyze HLA matching(low or high resolution ) on outcomes of umbilical cord blood transplantation(UCB) and the value of clinical application.
Methods
From October 2010 to July 2012,26 patients were selected umbilical cord blood transplantation in our hospital,in the absence of a suitable HLA-identical sibling donor or alternative donors.We examined the effects of HLA matching (low or high resolution ) on engraftment of leading, engraftment,graft-versus-host disease (GVHD), infection and mortality.Performed mainly by sequence-specific oligonucleotide probe (SSOP) methods, sequence-based typing (SBT) methods and high resolution sequence-specific primers(SSP) methods,retrospective HLA matching of cord blood,typed at high resolution for HLA-A,-B, -C, -DRB1, -DQ, and -DP and low resolution for HLA-A,B,DRB1.
Results
Compared single UBC units transplantation with double UBC units,the hematopoietic reconstitution rate was 88% vs 56%.The median total nucleated cells(TNC) of single and double cord blood was 5.5×107/kg, when TNC≥5×107/kg could promote neutrophil recoveries (p<0.05). The UBC units were a 6/10 HLA high resolution match or better with each other could promote UCB implantation advantaged?P<0.05?, accelerate platelet recovery?P<0.05?and reduce more risk of acute GVHD (grade III -IV)?P<0.05?.There are different between the group 5-6/6 HLA low resolution and 3-4/6 .but no statistical difference?P>0.05?.
Summary
The HLA High resolution typing can select the better UCB than HLA low-resoulution. It has important clinical value on promoting hematopoietic reconstitution and reducing complications after UCB transplation.
Keyword(s): Cord blood, HLA, Stem cell transplant
Session topic: Publication Only
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