INVASIVE YEAST INFECTIONS IN HEMATOLOGICAL PATIENTS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
Author(s): ,
Marina Popova
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Yuliya Rogacheva
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Alisa Volkova
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Inna Markova
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Anastasya Frolova
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Aleksandr Shvetcov
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Ilya Nikolaev
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Oleg Goloshchapov
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Tatiana Bykova
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Olesya Paina
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Asmik Gevorgian
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Elena Darskaya
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Marya Vladovskaya
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Sergey Bondarenko
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Ivan Moiseev
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Vadim Baykov
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Ludmila Zubarovskaya
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
,
Nicolay Klimko
Affiliations:
I.I. Mechnikov North-Western State Medical University,Saint Petersburg,Russian Federation;Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
Boris Afanasyev
Affiliations:
Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of St. Petersburg,Saint Petersburg,Russian Federation
EHA Library. Rogacheva Y. Jun 15, 2019; 266903; PS1286
Yuliya Rogacheva
Yuliya Rogacheva
Contributions
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Abstract

Abstract: PS1286

Type: Poster Presentation

Presentation during EHA24: On Saturday, June 15, 2019 from 17:30 - 19:00

Location: Poster area

Background
Invasive yeast infection is rare invasive fungal disease but associated with high mortality rate in hematological patients. Data on Invasive yeast infection in hematopoietic stem cell transplantation (HSCT) recipients are limited.

Aims

The aim of our study was to estimate epidemiology of invasive yeast infections in large HSCT recipients’ cohort for the 10-year period transplant activity in CIC725.

Methods

Between 2008 and 2017 2430 stem cell transplantation have been performed in CIC 725: 1647 allogeneic HSCT and 783 autologous HSCT. A retrospective study included 30 cases of invasive yeast infections in patients with hematological malignances and non-malignant hematological diseases after HSCT. EORTC/MSG 2008 criteria were used for the diagnosis of proven yeast infections as well as to evaluate response to therapy.

Results

Incidence of invasive yeast infections for the 10-year period of high transplant activity was 1,2%: 1,4% in allo-HSCT recipients (n=23), 0,9% – auto-HSCT (n=7) predominantly in patients with acute leukemia – 67% (n=20). The median age was 10 y.o. (range, 1 month-59 years). In study population allo-HSCT from unrelated donor was performed in 50% (n=15), haplo-HSCT in 27% (n=8) and auto-HSCT in 23% (n=7). In study cohort 30% of patients had no complete remission at the moment of HSCT. As a primary antifungal prophylaxis was used: fluconazole – 37% (n=11), echinocandins – 13% (n=4), without prophylaxis – 23% (n=7); as a secondary prophylaxis – voriconazole in 27% (n=8). The median day of onset of invasive yeast infections after allo-HSCT was 109 days (3-1337), auto-HSCT – 20 days (8-33). The etiology of invasive yeast infections was: Candida spp. – 87% (n=26), Malassezia furfur – 7% (n=2), Trichosporon asahii – 3% (n=1), Cryptococcus spp. – 3% (n=1). Febrile fever was the main clinical symptom and septic syndrome developed in 60% of cases. OS at 30 days from diagnosis of invasive yeast infection was 63%. The central venous catheter removal was the only factor significantly improved OS at 30 days after invasive yeast infection diagnosis (91% vs 17%, p=0,001).

Conclusion

Incidence of invasive yeast infections for the 10 years of observation was 1,2%: 1,4% in allo-HSCT recipients, 0,9% – auto-HSCT. The main etiology was Candida spp. (87%). Overall survival at 30 days from the diagnosis of invasive yeast infections was 60%. Removing of central venous catheter improved overall survival in hematological patients after HSCT with invasive yeast infections.

Session topic: 30. Infectious diseases

Keyword(s): Acute leukemia, Allogeneic hematopoietic stem cell transplant, Fungal infection

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