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Adherence To The Western, Prudent, And Mediterranean Dietary Patterns And Chronic Lymphocytic Leukemia In The MCC-Spain Study
EHA Library. Solans M.
Nov 1, 2018; 234402
Topic: 3Aj Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Marta Solans
Marta Solans
Contributions
Journal Abstract

Co-Authors: Adela Castelló, Yolanda Benavente, Rafael Marcos-Gragera, Pilar Amiano, Esther Gracia-Lavedan, Laura Costas, Claudia Robles, Eva Gonzalez-Barca, Esmeralda de la Banda, Esther Alonso, Marta Aymerich, Elias Campo, Trinidad Dierssen-Sotos, Guillermo Fernández-Tardón, Rocio Olmedo-Requena, Eva Gimeno, Gemma Castaño-Vinyals, Nuria Aragonés, Manolis Kogevinas, Silvia de Sanjose, Marina Pollán, Delphine Casabonne

Abstract: Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.

Article Number: 1881

Doi: 10.3324/haematol.2018.192526

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